Volume 11, Issue 42 (3-2021)
NCMBJ 2021, 11(42): 65-82 |
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Akhlaghi M, Ebrahimpour M, Ansari K, Parnian F, Zarezadeh Mehrizi M, Taebpour M et al . Synthesis, study and characterization of nano niosomal system containing Glycrrizha glabra extract in order to improve its therapeutic effects. NCMBJ 2021; 11 (42) :65-82
URL: http://ncmbjpiau.ir/article-1-1385-en.html
URL: http://ncmbjpiau.ir/article-1-1385-en.html
Milad Akhlaghi 
, Marziyeh Ebrahimpour , Kazem Ansari , Fatemeh Parnian , Maryam Zarezadeh Mehrizi , Mohammad Taebpour , Bibi fatemeh Haghirosadat
, Marziyeh Ebrahimpour , Kazem Ansari , Fatemeh Parnian , Maryam Zarezadeh Mehrizi , Mohammad Taebpour , Bibi fatemeh Haghirosadat
Department of clinical biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (2449 Views)
Aim and Background: The use of medical herbs and their extracts because of their low side effects is increasing all over the world. Glycrrizha glabra is one of these plants with proven therapeutic effects, but conventional prescribing of them faces challenges. Using of drug delivery nanocarriers such as Niosome is one of the new strategies to overcome these challenges. The aim of this study was to synthesis and charactrization of nano niosomal system containing Glycrrizha glabra extract in order to improve its therapeutic effects.
Material and methods: Nanoniosome were synthesized using Tween-60 (70%) and cholesterol (30%) by thin film method and by using inactive method, Glycrrizha glabra extract was loaded into them. Their physico-chemical features were assayed by Zeta sizer, AFM and FTIR and at last the release rate of extract and toxicity of Nanoniosome on normal cells were assayed.
Results: Data showed that the synthesized nanoniosomes are anionic with -21.2± 1.64 mV zeta potential, size of 90.7± 3.6 nm, dispersion index of 0.53 and 55.36% encapsulation efficiency. The nanoniosmal system presented slow and controlled release of the extract. AFM and FTIR analysis demonstrated that nanoparticles have appropriate morphology and the system does not interact with the extract. The results of MTT assay also approved that the system has not toxicity effects on normal cells.
Conclusion: The results indicated that synthesized nanosiosome vesicles because of their appropriate features, could be good carrier for delivering of Glycrrizha glabra extract and thus improve its therapeutic effects.
Material and methods: Nanoniosome were synthesized using Tween-60 (70%) and cholesterol (30%) by thin film method and by using inactive method, Glycrrizha glabra extract was loaded into them. Their physico-chemical features were assayed by Zeta sizer, AFM and FTIR and at last the release rate of extract and toxicity of Nanoniosome on normal cells were assayed.
Results: Data showed that the synthesized nanoniosomes are anionic with -21.2± 1.64 mV zeta potential, size of 90.7± 3.6 nm, dispersion index of 0.53 and 55.36% encapsulation efficiency. The nanoniosmal system presented slow and controlled release of the extract. AFM and FTIR analysis demonstrated that nanoparticles have appropriate morphology and the system does not interact with the extract. The results of MTT assay also approved that the system has not toxicity effects on normal cells.
Conclusion: The results indicated that synthesized nanosiosome vesicles because of their appropriate features, could be good carrier for delivering of Glycrrizha glabra extract and thus improve its therapeutic effects.
Type of Study: Research Article |
Subject:
Biochemistry
Received: 2021/04/11 | Accepted: 2021/05/22 | Published: 2021/06/21
Received: 2021/04/11 | Accepted: 2021/05/22 | Published: 2021/06/21
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